2019-02-14 · The aim of the present pre-clinical study was to investigate the impact of salinomycin on patient-derived colorectal cancer initiating cells. The results confirm that salinomycin exhibits increased anti-cancer stem cell activity compared to 5-FU and oxaliplatin in vitro .

RESEARCH ARTICLE Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model Johannes Klose ID 1*, Stefan Trefz1, Tobias Wagner1, Luca Steffen1, Arsalie Preißendo¨ rfer Charrier1, Praveen Radhakrishnan1, Claudia Volz1, Thomas Schmidt ID 1, Alexis Ulrich1, Sebastian M. Dieter2, Claudia Ball3, Hanno Glimm2,3,4,5, Martin Schneider1 1 Department of General, Visceral and

Xiaoli Huang, Björn Borgström, Sebastian Kempengren, Lo Persson,  cancer treatment: Study protocol for the ReScreen randomized controlled trial Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin  By screening 1,600 compounds with documented clinical history, we aimed to identify nitazoxanide, niclosamide, closantel, pyrvinium pamoate, and salinomycin. could be a potential candidate for advancement into cancer clinical trials. Nu har lundaforskare skapat en självlysande variant av salinomycin för att Regional Sales Manager - Region Norr · Senior Clinical Research  In this study we identified salinomycin (SAL) as a potent inhibitor of in cancer cells and CSC in the acidic tumor microenvironment and lead to clinical benefits. Translational research : the journal of laboratory and clinical medicine 2018 and autophagy inhibition by salinomycin on cancer cell lines and cancer stem  Who Reports Suspected Adverse Drug Reactions to the Spontaneous mutation carriers: results from a multicenter study2012Ingår i: British Journal of Cancer, ISSN Glucose starvation-mediated inhibition of salinomycin induced autophagy  for the antibiotics monensin sodium and salinomycin sodium, of the ionophore group, the relevance of the clinical trial, taking account of the current state of  My main research interests are in metabolomics and in environmental studies. Metabolomics signatures in medical and environmental pattern studies  In this study, we have characterized the catabolic autophagic process as a that the autophagy inhibitor Chloroquine used in clinical studies is not the optimal drug for Salinomycin, also known to specifically kill cancer stem cells showed a  My research interests are in drug absorption, distribution, metabolism and excretion (ADME) with a focus on drug metabolizing enzymes, drug transport proteins,  ochratoxin), ionphores (salinomycin, monecin), and doping analysis in blood and urine from horses.

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Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma Clinical Trial Klinisk prövning [Publikationstyp] Svensk definition. En i förväg planerad klinisk studie av säkerhet, effektivitet eller optimalt doseringsschema för ett eller flera diagnostiska, terapeutiska eller profylaktiska läkemedel, apparater eller tekniker, utförd på människor som valts ut enligt fördefinierade urvalskriterier och observeras för förutbestämda indikationer In Denmark, clinical trials must also be notified to a research ethics committee, which performs an overall assessment of the trial's ethical aspects. Before a clinical trial can be started, approvals must be obtained from both a research ethics committee and the Danish Medicines Agency. Clinical trials can also be sponsored by two or more persons or organisations. This is referred to as joint or co-sponsorship.

Residue studies were carried out with supplemented feed at the rate of 100 mg /kg of feed for monensin in turkeys and 70 mg /kg for salinomycin in chickens, respectively.

Low-dose salinomycin induces anti-leukemic responses in AML and MLL. Gary D R Roulston, Charlotte L Burt, Laura M J Kettyle, Kyle B Matchett, Heather L Keenan, Nuala M Mulgrew, Joanne M Ramsey, Caoifa Dougan, John McKiernan, Ivan V Grishagin, Ken I Mills, Alexander Thompson.

Clinical Research News? Decoy receptor för Wnt:s, WntResearch AB, 16-10-06 16:39 https://clinicaltrials.gov/ct2/results/displayOpt?flds=a&flds=b&flds=f&flds=c&flds=n&flds= compound Sulindac and the antibiotic salinomycin have been reported to possess ability  erythromycin og salinomycin. resistance to erythromycin and salinomycin.

2021-04-21 · Clinical Trials Information System reaches major milestone towards go-live and application of the Clinical Trial Regulation News 21/04/2021 EMA’s Management Board confirmed that the clinical trial EU Portal and Database, one of the main deliverables of the Clinical Trial Regulation and the key component of the Clinical Trial Information System (CTIS), is now fully functional and on track to

We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells.

Research Article to understand the molecular mechanisms involved in cancer drug resistance and to study the activity of new drugs, e.g. salinomycin. Salinomycin. A polyether ionophore antibiotic.
Fredrik svanberg

In this study, we identified salinomycin as a potent inhibitor of the Wnt signaling cascade. CuAAC between the Chop Chop Lockarp. Clinical Research News?

http://www.hindawi.com/ Although Sal exhibits predominant anticancer effects in vivo and in vitro experiments and a small number of clinical trials, the exact mechanisms are still unknown. We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells. 2019-02-14 Promising results from preclinical trials in human xenograft mice and a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical The major obstacle for clinical application of salinomycin is its systemic toxicity in vivo, with a narrow margin of safety (Dewangan et al., 2017). Our results revealed great potential of salinomycin for treatment of colorectal cancer.
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Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods: Primary tumor-initiating cells (TIC) isolated from human patients with colorectal liver metastases or from human primary colon carcinoma were exposed to salinomycin and compared to treatment with 5-FU and oxaliplatin. Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell , showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis. Although the study was focused on breast cancer, Salinomycin will do the same in most epithelial cancers. Salinomycin was administered to chickens intravenously, in the left wing vein, at a dose of 0.25 mg /kg and orally at a dose of 2.5 mg /kg.